Here, we propose a generalization of the central dogma as a division of labour between the transmission and expression of information: the transmitter (nucleic acids) perpetuates information across generations,…
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1. Generalizing the central dogma as a cross-hierarchical principle of biology - PubMed
Here, we propose a generalization of the central dogma as a division of labour between the transmission and expression of information: the transmitter (nucleic acids) perpetuates information across generations, whereas the expressor (protein) enacts this information to facilitate the transmitter's function without itself perpetuating information.
Generalizing the central dogma as a cross-hierarchical principle of biology
Philos Trans R Soc Lond B Biol Sci. 2025 Oct 2;380(1936):20240296.
doi: 10.1098/rstb.2024.0296.
Epub 2025 Oct 2.
...
The central dogma of molecular biology, as originally proposed by Crick, asserts that information passed into protein cannot flow back out.
2. Central Dogma Cycle and Network: A Model for Cell Memory
molecular biology to a more dynamic model termed the Central Dogma Cycle (CDC)
This is a preprint.
It has not yet been peer reviewed by a journal.
...
ArXiv [Preprint].
2025 Jun 19:arXiv:2506.16374v1.
Central Dogma Cycle and Network: A Model for Cell Memory
PMCID: PMC12447708 PMID: 40980751
This paper proposes an extension of the traditional Central Dogma of
and a broader network called the Central Dogma Cyclic Network (CDCN).
Central Dogma is necessary for genetic information flow, it is not sufficient
to fully explain cellular memory and informa
3. Find Central Dogma Again
GPT-like LLMs to utilize language transfer capabilities to rediscover the genetic code rules of the central dogma.
In our experimental design, we transformed the central dogma into a binary classification problem of aligning DNA sequences with protein sequences, where positive examples are matching DNA and protein sequences, and negative examples are non-matching pairs.
We first trained a GPT-2 model from scratch using a dataset comprising protein sequences,
DNA sequences, and sequences from languages such as English and Chinese.
4. Central Dogma Cycle and Network: A Model for Cell Memory - PMC
This paper proposes an extension of the traditional Central Dogma of molecular biology to a more dynamic model termed the Central Dogma cycle (CDC) and a broader network called the Central Dogma cyclic network (CDCN).
Central Dogma Cycle and Network: A Model for Cell Memory - PMC
Bioessays.
2026 May 12;48:e70143.
...
Central Dogma Cycle and Network: A Model for Cell Memory
While the Central Dogma is necessary for genetic information flow, i
5. Exploration of the Central Dogma at the Interface of Chemistry and Biologypmc.ncbi.nlm.nih.gov › articles › PMC2946126
Two exciting talks at the symposium — one by Dr. Anna Pyle (Yale University) on self-splicing group II intron RNA and the other by Dr. Hiroaki Suga (University of Tokyo) on non-natural peptide synthesis — extended our understanding of this dogma.
Exploration of the Central Dogma at the Interface of Chemistry and Biology
Ever since the term “central dogma” was coined in 1958, researchers have sought to control information flow from nucleic acids to proteins.
Talks delivered by Drs.
Anna Pyle and Hiroaki Suga at this year’s Chemical Biology Symposium at Yale in May 2010 applauded recent advances in this area, at the interface between chemistry and biology.
6. Generalizing the central dogma as a cross-hierarchical ... - PMC
Specifically, we review a mathematical model suggesting that the central dogma originates through spontaneous symmetry breaking driven by evolutionary conflicts between different levels of selection.
Generalizing the central dogma as a cross-hierarchical principle of biology
The central dogma of molecular biology, as originally proposed by Crick, asserts that information passed into protein cannot flow back out.
This principle has been interpreted as underpinning modern understandings of heredity and evolution, implying the unidirectionality of information flow from nucleic acids to proteins.
Here, we propose a generalization of the central dogma as a division of labour between